Runtime behavior alerts of this type inform the user that an attempt has been made to modify the registry in order for a file or files to be loaded when the computer is booted in safe mode. Any attempt at this behavior by an unauthorized program could indicate a malware infection.
Please note that the behavior of some legitimate product installers can sometimes resemble that of malware. For this reason, installing or updating software carries an increased likelihood of unwanted HIPS detections and we recommend configuring HIPS to Alert Only mode for the duration of any product installs or updates. For further information please refer to the following knowledgebase article deciding whether to allow or block a file.